Effect of hesperidin and naringin on the plasma lipid profile and plasma antioxidant activity in rats fed a cholesterol‐containing diet
Identifieur interne : 002394 ( Main/Exploration ); précédent : 002393; suivant : 002395Effect of hesperidin and naringin on the plasma lipid profile and plasma antioxidant activity in rats fed a cholesterol‐containing diet
Auteurs : Shela Gorinstein [Israël] ; Hanna Leontowicz [Pologne] ; Maria Leontowicz [Pologne] ; Ryszard Krzeminski [Pologne] ; Mikolaj Gralak [Pologne] ; Zenon Jastrzebski [Pologne] ; Yong-Seo Park [Corée du Sud] ; Soon-Teck Jung [Corée du Sud] ; Seong-Gook Kang [Corée du Sud] ; Simon Trakhtenberg [Israël]Source :
- Journal of the Science of Food and Agriculture [ 0022-5142 ] ; 2007-05.
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- KwdEn :
Abstract
The objective of this study was to compare the influence of hesperidin and naringin, the main flavonones of orange and grapefruit, on plasma lipid profile and antioxidant activity in rats fed a cholesterol‐containing diet. Sixty male Wistar rats were randomly divided into six groups of 10, named Control, Hesperidin, Naringin, Chol, Chol/Hesperidin and Chol/Naringin. The Control group was fed a basal diet (BD) and 1–2 mL of distilled water. To the BD of the other five groups were added 0.1–0.2 mg of hesperidin dissolved in 1–2 mL of distilled water (Hesperidin group), 0.46–0.92 mg of naringin in 1–2 mL of water (Naringin group), 1% of non‐oxidised cholesterol (NOC) and 1–2 mL of water (Chol), 1% of NOC and 0.1–0.2 mg of hesperidin in 1–2 mL of water (Chol/Hesperidin), 1% of NOC and 0.46–0.92 mg of naringin in 1–2 mL of water (Chol/Naringin). After 30 days of the experiment it was found that the diets supplemented with hesperidin and naringin increased the plasma antioxidant activity. In conclusion, diets supplemented with hesperidin and naringin significantly hindered the increase in plasma lipid levels caused by cholesterol feeding. Hesperidin and naringin, bioactive compounds of citrus fruits, are powerful plasma lipid lowering and plasma antioxidant activity increasing flavonones. Copyright © 2007 Society of Chemical Industry
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DOI: 10.1002/jsfa.2834
Affiliations:
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Sci. Food Agric.</title><idno type="ISSN">0022-5142</idno><idno type="eISSN">1097-0010</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2007-05">2007-05</date><biblScope unit="volume">87</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1257">1257</biblScope><biblScope unit="page" to="1262">1262</biblScope></imprint><idno type="ISSN">0022-5142</idno></series><idno type="istex">E76EE45D7E8742A7D8886EB0DC8EDEADD620513A</idno><idno type="DOI">10.1002/jsfa.2834</idno><idno type="ArticleID">JSFA2834</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-5142</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>hesperidin</term><term>naringin</term><term>plasma antioxidant activity</term><term>plasma lipids</term><term>rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to compare the influence of hesperidin and naringin, the main flavonones of orange and grapefruit, on plasma lipid profile and antioxidant activity in rats fed a cholesterol‐containing diet. Sixty male Wistar rats were randomly divided into six groups of 10, named Control, Hesperidin, Naringin, Chol, Chol/Hesperidin and Chol/Naringin. The Control group was fed a basal diet (BD) and 1–2 mL of distilled water. To the BD of the other five groups were added 0.1–0.2 mg of hesperidin dissolved in 1–2 mL of distilled water (Hesperidin group), 0.46–0.92 mg of naringin in 1–2 mL of water (Naringin group), 1% of non‐oxidised cholesterol (NOC) and 1–2 mL of water (Chol), 1% of NOC and 0.1–0.2 mg of hesperidin in 1–2 mL of water (Chol/Hesperidin), 1% of NOC and 0.46–0.92 mg of naringin in 1–2 mL of water (Chol/Naringin). After 30 days of the experiment it was found that the diets supplemented with hesperidin and naringin increased the plasma antioxidant activity. In conclusion, diets supplemented with hesperidin and naringin significantly hindered the increase in plasma lipid levels caused by cholesterol feeding. Hesperidin and naringin, bioactive compounds of citrus fruits, are powerful plasma lipid lowering and plasma antioxidant activity increasing flavonones. Copyright © 2007 Society of Chemical Industry</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Israël</li><li>Pologne</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Gorinstein, Shela" sort="Gorinstein, Shela" uniqKey="Gorinstein S" first="Shela" last="Gorinstein">Shela Gorinstein</name></noRegion><name sortKey="Trakhtenberg, Simon" sort="Trakhtenberg, Simon" uniqKey="Trakhtenberg S" first="Simon" last="Trakhtenberg">Simon Trakhtenberg</name></country><country name="Pologne"><noRegion><name sortKey="Leontowicz, Hanna" sort="Leontowicz, Hanna" uniqKey="Leontowicz H" first="Hanna" last="Leontowicz">Hanna Leontowicz</name></noRegion><name sortKey="Gralak, Mikolaj" sort="Gralak, Mikolaj" uniqKey="Gralak M" first="Mikolaj" last="Gralak">Mikolaj Gralak</name><name sortKey="Jastrzebski, Zenon" sort="Jastrzebski, Zenon" uniqKey="Jastrzebski Z" first="Zenon" last="Jastrzebski">Zenon Jastrzebski</name><name sortKey="Krzeminski, Ryszard" sort="Krzeminski, Ryszard" uniqKey="Krzeminski R" first="Ryszard" last="Krzeminski">Ryszard Krzeminski</name><name sortKey="Leontowicz, Maria" sort="Leontowicz, Maria" uniqKey="Leontowicz M" first="Maria" last="Leontowicz">Maria Leontowicz</name></country><country name="Corée du Sud"><noRegion><name sortKey="Park, Yong Eo" sort="Park, Yong Eo" uniqKey="Park Y" first="Yong-Seo" last="Park">Yong-Seo Park</name></noRegion><name sortKey="Jung, Soon Eck" sort="Jung, Soon Eck" uniqKey="Jung S" first="Soon-Teck" last="Jung">Soon-Teck Jung</name><name sortKey="Kang, Seong Ook" sort="Kang, Seong Ook" uniqKey="Kang S" first="Seong-Gook" last="Kang">Seong-Gook Kang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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